Abstract
Cationic lysosomal proteins such as cationic leukocyte antigen (CLA) and lysozyme were estimated in leukocyte lysates of acute and chronic leukaemics using quantitative enzymatic and immunoprecipitation techniques. The studies demonstrate that both lysosomal conponents are markers of non-lymphatic leukaemias. Therefore the determination of CLA and lysozyme is valuable for the differential diagnosis of acute leukaemias. The intracellular cationic protein contents showed characteristic kinetic variations as showing during X-irradiation of the spleen in cases of chronic myelocytic leukaemia. White cells in leukocytosis could be distinguished from normals by remarkably low cationic protein contents in leukocyte lysates. The results are interpreted in the light of current results revealed by immunofluorescent analyses.
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