Dynamics of cytochemical parameters of blood neutrophils in pregnant women with diffuse toxic goiter

Abstract

Introduction. Using cytochemical methods, the activity of myeloperoxidase (MPO), as well as the content of cationic proteins, glycogen and lipids in the blood neutrophils of pregnant women with diffuse toxic goiter (DTG) was studied in a comparative aspect.Goal. To study the dynamics of changes in the cytochemical parameters of neutrophils in women's blood during physiological pregnancy, as well as in pregnant patients with DTG.Material and methods. The study included 82 pregnant women aged 20-40 years old with Hashimoto's thyroiditis and graves' disease. The subject of the study was the determination of immunological indicators: the level of autoantibodies to TSH, TPO and TG; the content of populations and subpopulations of lymphocytes, and cytochemical indicators of blood: MPO activity; cationic protein content; glycogen content; lipid content. Results. The activity of MPO in the blood neutrophils of women with a physiological course of pregnancy (comparison group) is similar to that in the control group. In the first trimester of pregnancy, the percentage of neutrophils with a moderate to high content of colored granules tends to decrease, which is reflected in the value of the average cytochemical index.Conclusion. It should be noted that significant shifts in the content of components of the phagocytic defense system were found in the blood neutrophils of pregnant women with thyrotoxicosis syndrome.