Abstract
Decreases in the extracellular calcium concentration ([Ca 2+] o), induced by tetanization of the Schaffer collaterals in rat hippocampal slices, were measured by means of Ca 2+-sensitive microelectrodes. The amount of long term potentiation (LTP) of the evoked field potentials, induced by this tetanus, was determined. A positive correlation was found between the amplitude of the tetanus induced decrease in [Ca 2+] o and the amount of LTP that was elicited. The N-methyl- d-aspartate (NMDA) receptor antagonist 2-aminophosphonovalerate decreased both the tetanus-induced decreases in [Ca 2+] o and the amount of LTP that was induced. We conclude that the amount of Ca 2+ that enters the cell during a tetanus is of major importance in the induction process of LTP.
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