Abstract
SummaryThe qualitative iodoxybenzoate test of Leake has been found suitable for quantitative adaptation to the estimation of morphine. Methods for determining morphine in biological fluids and a rapid method of accurately checking the morphine content of morphine hydrochloride are suggested.Development of a satisfactorily accurate quantitative application of the usual color reactions for morphine has been retarded because of their general lack of (a) proper selectivity for this single opium alkaloid, (b) permanence of hue produced or (c) sufficient sensitivity. In addition such reactions are in most instances dependent to an undesirable degree on the temperature and pH of the test solution and the presence of commonly occurring contaminants. This situation is not surprising since most of these reactions are supposedly due to the formation of complex unstable chromogenic substances. A more ideal quantitative test should be the stoichiometric conversion of morphine to a simple colored form.Leake1 suggested ...
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