Quantitative Assessment of the Association between ABC Polymorphisms and Osteosarcoma Response: a Meta-analysis.

Xu Chen,Min Jiang,Guo-Hao Gu,Rui-Ke Zhao

doi:10.7314/apjcp.2015.16.11.4659

Abstract

ABC proteins are one key type of transport superfamilies which undertake majority of drug transport, which affect the osteosarcoma response to chemotherapeutics. Previous studies have suggested the association between ABC polymorphisms and osteosarcoma response. However, the results of previous studies remain controversial. Therefore, we perform a meta-analysis to get a more precise estimation of this association. The association between ABC polymorphisms and osteosarcoma response was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Three polymorphisms of ABC including ABCB1 rs1128503, ABCC3 rs4148416 and ABCC2 rs717620 polymorphism were investigated. Overall, significant association was observed between ABCC3 rs4148416 polymorphism and osteosarcoma response under allele contrast (T vs. C: OR=1.73, 95%CI=1.09-2.74, P=0.019), homozygote comparison (TT vs. CC: OR=2.00, 95%CI=1.25-3.23, P=0.004), recessive genetic model (TT vs. OR=1.80, 95%CI=1.14-2.84, P=0.011) and dominant genetic model (TT/TC vs. CC: OR=1.70, 95%CI=1.20-2.42, P=0.003). Moreover, significant association was also observed in Caucasian population rather than Asian population for ABCB1 rs1128503 polymorphism. We conclude that ABCC3 rs4148416 polymorphism was significantly associated with poor osteosarcoma response and ABCB1 rs1128503 polymorphism was significantly associated with good osteosarcoma response in Caucasian population rather than Asian population.

Highlights

Osteosarcoma, as one of the most common type of bone tumor in the world, is the leading cause of death in children less than fifteen years old (Ottaviani and Jaffe, 2009, He et al, 2014, Li et al, 2014)
Significant association was observed between ABCC3 rs4148416 polymorphism and osteosarcoma response under allele contrast (T vs. C: odds ratios (ORs)=1.73, 95%confidence intervals (CIs)=1.09-2.74, P=0.019), homozygote comparison (TT vs. CC: OR=2.00, 95%CI=1.25-3.23, P=0.004), recessive genetic model (TT vs. TC/CC: OR=1.80, 95%CI=1.14-2.84, P=0.011) and dominant genetic model (TT/TC vs. CC: OR=1.70, 95%CI=1.20-2.42, P=0.003)
We conclude that ABCC3 rs4148416 polymorphism was significantly associated with poor osteosarcoma response and ABCB1 rs1128503 polymorphism was significantly associated with good osteosarcoma response in Caucasian population rather than Asian population

Summary

Introduction

Osteosarcoma, as one of the most common type of bone tumor in the world, is the leading cause of death in children less than fifteen years old (Ottaviani and Jaffe, 2009, He et al, 2014, Li et al, 2014). The above treatment for osteosarcoma could not solve all the problems because about thirty percent of patients showed recurrence or metastasis within five years (Ottaviani and Jaffe, 2009). Previous studies have suggested the association between ABC polymorphisms and osteosarcoma response. The association between ABC polymorphisms and osteosarcoma response was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Significant association was observed between ABCC3 rs4148416 polymorphism and osteosarcoma response under allele contrast (T vs C: OR=1.73, 95%CI=1.09-2.74, P=0.019), homozygote comparison (TT vs CC: OR=2.00, 95%CI=1.25-3.23, P=0.004), recessive genetic model (TT vs TC/CC: OR=1.80, 95%CI=1.14-2.84, P=0.011) and dominant genetic model (TT/TC vs CC: OR=1.70, 95%CI=1.20-2.42, P=0.003). Significant association was observed in Caucasian population rather than Asian population for ABCB1 rs1128503 polymorphism. We conclude that ABCC3 rs4148416 polymorphism was significantly associated with poor osteosarcoma response and ABCB1 rs1128503 polymorphism was significantly associated with good osteosarcoma response in Caucasian population rather than Asian population

Methods

Results

Conclusion