Abstract
Polymorphisms in the apolipoprotein C-III (APOC3) gene have been reported to be associated with coronary heart disease (CHD), but the data so far have been conflicting. To derive a more precise estimation of these associations, we performed a meta-analysis to investigate the three main polymorphisms (SstI, T-455C, C-482T) of APOC3 in all published studies. Databases including PubMed, Web of Science, Wanfang, SinoMed and CNKI were systematically searched. The association was assessed using odds ratios (ORs) with 95% confidence intervals (CIs). The statistical analysis was performed using Review Manager 5.3.3 and Stata 12.0. A total of 31 studies have been identified. The pooled odds ratio (OR) for the association between the APOC3 gene polymorphisms and CHD and its corresponding 95% confidence interval (95% CI) were evaluated by random or fixed effect models. A statistical association between APOC3 SstI polymorphism and CHD susceptibility was observed under an allelic contrast model (P= 0.003, OR = 1.14, 95% CI = 1.05-1.24), dominant genetic model (P= 0.01, OR = 1.14, 95% CI = 1.03-1.26), and recessive genetic model (P= 0.02, OR = 1.35, 95% CI = 1.06-1.71), respectively. A significant association between the APOC3 T-455C polymorphism and CHD was also detected under an allelic contrast (P < 0.0001, OR = 1.19, 95% CI = 1.10-1.29), dominant genetic model (P= 0.0003, OR = 1.24, 95% CI = 1.11-1.39) and recessive genetic model (P= 0.04, OR = 1.30, 95% CI = 1.01-1.67). No significant association between the APOC3 C-482T polymorphism and CHD was found under an allelic model (P= 0.94, OR = 1.00, 95% CI = 0.93-1.08), dominant genetic model (P= 0.20, OR = 1.07, 95% CI = 0.97-1.18) or recessive genetic model (P= 0.13, OR = 0.90, 95% CI = 0.79-1.03). This meta-analysis revealed that the APOC3 SstI and T-455C polymorphisms significantly increase CHD susceptibility. No significant association was observed between the APOC3 C-482T polymorphism and CHD susceptibility.
Highlights
Polymorphisms in the apolipoprotein C-III (APOC3) gene have been reported to be associated with coronary heart disease (CHD), but the data so far have been conflicting
As for the APOC C-482T polymorphism and its relationship to CHD, no significant heterogeneity was found under the allelic contrast model (I2 = 0%, P = 0.56), the dominant genetic model (I2 = 0%, P = 0.82) or the recessive genetic model (I2 = 15%, P = 0.30)
The results showed that the APOC3 SstI and T-455C polymorphisms significantly increase CHD susceptibility
Summary
Polymorphisms in the apolipoprotein C-III (APOC3) gene have been reported to be associated with coronary heart disease (CHD), but the data so far have been conflicting. A statistical association between APOC3 SstI polymorphism and CHD susceptibility was observed under an allelic contrast model (P = 0.003, OR = 1.14, 95% CI = 1.051.24), dominant genetic model (P = 0.01, OR = 1.14, 95% CI = 1.03-1.26), and recessive genetic model (P = 0.02, OR = 1.35, 95% CI = 1.06-1.71), respectively. No significant association between the APOC3 C-482T polymorphism and CHD was found under an allelic model (P = 0.94, OR = 1.00, 95% CI = 0.93-1.08), dominant genetic model (P = 0.20, OR = 1.07, 95% CI = 0.97-1.18) or recessive genetic model (P = 0.13, OR = 0.90, 95% CI = 0.79-1.03) This meta-analysis revealed that the APOC3 SstI and T-455C polymorphisms significantly increase CHD susceptibility. We conducted a meta-analysis of the existing published studies on this topic to evaluate the strength of the association between the three main APOC3 polymorphisms (SstI, T-455C, C-482T) and CHD
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