Quantitative and Histological Study of the Effect of Cadmium Oxide on Both Body and Kidney of Mice

Abstract

The present study was conducted using 24 normal male of Swiss white mice weighing (36-40 gm), 70 days old .The mice were divided into four groups of six mice each. The mice of control group were fed pellet and given tap water during the entire period of the experiment (30 days).The other three groups of mice were given cadmium oxide orally at doses of (7.0 mg / kg body wt., 14.1 mg / kg body wt., and 22.3 mg / kg body wt.) consecutively every day for 30 days and weight in gm was taken once a week. With standard histological techniques, samples were obtained from kidney of the mice. The body weights along with kidney weights were decreased with increase of doses. Also it has been concluded that cadmium oxide caused damages in renal corpuscle (Bowman’s capsule and glomerulus) and renal cortical tubules as well as decrease in body weight and kidney weight (wt.).