Abstract
Research based on quantitative analysis, pharmacokinetics and metabolomics was conducted to explore the effects of salt-processing on Psoraleae Fructus (PF). Quantitative analysis showed that the contents of bioactive components were higher in salt-processed Psoraleae Fructus (SPF) extract than in PF extract. Pharmacokinetics indicated that the overall AUC and tmax levels was higher, while Cmax was lower in the SPF group. In the metabolomics study, the differential influences of PF and SPF on 22 common biomarkers and associated metabolic pathways showed that salt-processing could enhance the effect of PF and reduce toxicity in the cardiovascular and renal systems. The internal correlations among these results, together with the influence of salt-processing, suggested that the effects of heating and newly generated surfactants during the salt-processing procedure were the primary causes of the changes in chemical composition and absorption characteristics, as well as the subsequent enhanced efficacy and minor toxicity.
Highlights
Psoralea corylifolia L., a member of the Leguminosae family, is widely distributed in China, India, Burma and Sri Lanka[1]
In light of the above, a novel strategy based on quantitative analysis, pharmacokinetics and metabolomics was proposed in this study to explore the internal correlations among chemical composition, absorption characteristics and comprehensive efficacy, as well as the influence of salt-processing
Quantitative analysis of bioactive components in Psoraleae Fructus (PF) and salt-processed Psoraleae Fructus (SPF) extracts was carried out to ascertain the alteration in chemical composition
Summary
Psoralea corylifolia L., a member of the Leguminosae family, is widely distributed in China, India, Burma and Sri Lanka[1]. Salt-processed Psoraleae Fructus (SPF), the most commonly used PF product in the clinic, exhibits stronger efficiency and minor toxicity in the renal system than PF. The herb-processing method, which is based on herb characteristics and medical need, has been assisting TCM in developing reasonable curative effects for a long time. Most research about processing-methods only focused on alterations in chemical composition[9,10] or curative effects[11] individually. In light of the above, a novel strategy based on quantitative analysis, pharmacokinetics and metabolomics was proposed in this study to explore the internal correlations among chemical composition, absorption characteristics and comprehensive efficacy, as well as the influence of salt-processing. Quantitative analysis of bioactive components in PF and SPF extracts was carried out to ascertain the alteration in chemical composition. The internal correlations among these results, together with the influence of salt-processing, were comprehensively analysed to reveal the mechanism of salt-processing on PF
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