Abstract
A rapid, sensitive and specific high-performance liquid chromatographic assay for the quantification of nifedipine in human plasma was developed, satisfactorily validated and applied to samples of plasma from healthy volunteers. The sample pre-treatment incorporating protein denaturation by urea and ethyl acetate extraction compared favourably in terms of selectivity with previously published methods. The limit of quantitation of this reversed-phase LC method was 7.0 ng ml −1 for the analysis of 0.5 ml samples.
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