Abstract
A sensitive, specific and reliable assay utilizing a combined gas chromatography—mass spectrometry—selected ion monitoring technique is described for the quantitative determination of melperone, a neuroleptic agent, in human plasma. Using a 2-ml plasma sample, the method is sensitive and has acceptable precision in the range of 1 to 100 ng/ml. The method is applied in a limited bioavailability study and found to be adequate. A plasma metabolite was isolated and identified in the clinical samples.
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Schedule a callMore From: Journal of Chromatography B: Biomedical Sciences and Applications
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