Abstract
A high-performance liquid chromatographic (HPLC) assay method for C 60 fullerene, in blood, liver and spleen using photodiode-array detection or mass spectrometric detection (LC–MS) and C 70 fullerene, as the internal standard, is described. The recovery from mouse blood and tissues spiked with micronized C 60 exceeds 90%. The method is linear from 0.05 to 200 mg of C 60 per liter of blood and from 0.05 to 5.00% of C 60 per tissue weight. The limit of detection of the method is 0.1 ng of C 60 per injection. This method was applied to mouse blood and tissue samples after intraperitoneal administration of a micronized C 60 suspension.
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