Abstract
Methods for quantitative chromatographic separation and spectrophotometric analysis are reported for allopurinol [4-hydroxypyrazolo(3,4,-<i>d</i>) pyrimidine] in the presence of its alkaline decomposition products. Stability data are presented using rate constants obtained from Arrhenius-type plots; t<sub>90</sub>% for an unbuffered sodium allopurinol solution is approximately 150 days at 25°. The formate salt of 3-amino-4-pyrazolecarboxamide accounts for essentially all the degradation under pharmaceutically usable conditions.
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