Abstract
An analytical method was developed in order to obtain qualitative and quantitative information on pyrrolizidine alkaloid mixtures from Senecio vulgaris L. (Compositae) by means of 1H Fourier Transform Nuclear Magnetic Resonance spectroscopy. It was found that this plant contains not only seneciphylline, senecionine and retrorsine, but also the corresponding geometrical E-isomers spartioidine, integerrimine and usaramine. Some general instrumental conditions necessary for quantitative FT NMR were established, which enabled us to determine the total alkaloid level, the N-oxide level, the total Z/E ratio, and the amount of each Z/E isomer pair with good precision. The possibilities of using this method to analyze pyrrolizidine mixtures from other Senecio sp., and some advantages and limitations of quantitative analysis by means of 1H FT NMR are discussed.
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