Abstract
Quantifying passive myocardial stiffness and wall stress in heart failure patients using personalized ventricular mechanics
Highlights
Heart failure (HF) patients present with a spectrum of phenotypes, including preserved ejection fraction (HFpEF) and reduced EF (HFrEF)
left ventricular (LV) finite element mechanical models were personalized using LV surface data segmented from cine cardiac magnetic resonance (CMR) images
A mechanical simulation of LV diastolic filling was optimized to each patient-specific geometry and pressure loading, incorporating non-linear myocardial anisotropic tissue behavior and myocyte fiber orientation derived from our published work
Summary
This study aimed to quantify passive mechanical properties in HFrEF and HFpEF patients using personalised left ventricular (LV) biomechanical analysis
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