Abstract
Objective: Oxidative stress status in subgroup of heart failure (HF) syndrome still remains unknown. We aimed to study Total Antioxidant Status (TAS), Total Oxidant Status (TOS) and Oxidative Stress Index (OSI) in both systolic and diastolic HF, and also in both ischemic and non-ischemic HF. Materials and Methods: Consecutive 123 chronic HF patients were included in this cross-sectional study. Group 1 consisted of 73 systolic HF patients (50 ischemic patients and 23 non-ischemic patients) and group 2 consisted of 50 diastolic HF patients. As a control group (group 3), 37 healthy subjects were included. Echocardiographic evaluation was performed and TAS, TOS and OSI were studied in all patients. Results: The highest TAS value (1.10±0.24) was found in Group 1, but the lowest in Group 2 (0.90±0.14). Diastolic HF group had the highest TOS value (37.2±10.41) while systolic HF group (32.9±7.26) and control group (26.19±8.00) followed it. OSI was found the highest in diastolic HF group (4.37±1.24) and the lowest in systolic HF group (2.24±0.80). TOS and OSI were similar between ischemic and non-ischemic subgroups of systolic HF but TAS was statistically higher in non-ischemic (p:0.0005). Conclusions: We found higher oxidative stress in HF patients, predominantly in diastolic HF patients. The difference between diastolic and systolic HF with regard to oxidative and antioxidative status seems to come from distinct drugs usage between the groups, which have potential effects on oxidative and antioxidative parameters. To reduce, at least, oxidative stress in diastolic HF patients, medical therapy is needed.
Highlights
Congestive heart failure (HF) is a progressive clinical syndrome that affects the pumping power of the heart muscles leading to buildup of fluid around the heart and increased left ventricular filling pressures [1]
The difference between diastolic and systolic HF with regard to oxidative and antioxidative status seems to come from distinct drugs usage between the groups, which have potential effects on oxidative and antioxidative parameters
We aimed to study Total Antioxidant Status (TAS), Total Oxidant Status (TOS) and Oxidative Stress Index (OSI) in both systolic and diastolic HF, and in ischemic and non-ischemic HF
Summary
Congestive heart failure (HF) is a progressive clinical syndrome that affects the pumping power of the heart muscles leading to buildup of fluid around the heart and increased left ventricular filling pressures [1]. HF can lead to myocardial, valvular, pericardial or non-cardiac pathologies and can affect various organ functions such as renal, pulmonary, endocrine and skeletal muscle [1,2]. While reactive oxygen species (ROS) are continuously produced by many tissues, they are eliminated by antioxidant defense systems. Increase in radical productions or decrease in antioxidant defenses give rise to oxidative stress. Increased ROS damage biological structures [3]. Proteins and nucleic acids may aggravate current disease or lead to occurrence of new diseases [4]
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