Correlation of brain natriuretic peptide with parameters of heart function in patients with diastolic heart failure

Abstract

Objective To investigate the correlation of plasma B -type natriuretic peptide(BNP)level with echocardiographic functional parameters and P - wave terminal force - V1 (Pff V1). Methods Two hundred and eighty -nine consecutive patients in hospital were divided into three groups: normal heart function group(n = 91), diastolic heart failure group (n = 149), diastolic and systolic heart failure group (n = 49). According to the results of ratio of mitral annular early diastole to late diastole (EV/AV), the DHF patients were subdivided into DHF 1 group EV/AV 1.5 (n = 43). Blood BNP levels were determined by BNP Tri-age test device, LVEF, LVEDD, LAD were examined with echocardiogram, and Pff V1 were measured by e-lectrocardiogram in five groups in hospital, then made a statistical analysis for the results. Results In five groups,The plasma BNP levels elevated with the worsening of heart failure, with significant differences a-mong the patients with different group. In diastolic heart failure group, the plasma BNP level were signifi-cant positively correlated withLAD (r =0. 711, P <0.01), but significant negatively correlated with PtfV1(r = -0.615, P < 0.01). In diastolic and systolic heart failure group, the plasma BNP levels were significant positively correlated with LVEDD (r =0. 862, P <0. 01), but significant negatively correlated with LVEF (r = -0.926, P <0.01). Conclusions Measuring the plasma BNP level, combined with the ratio of E to A classification, echocardiographic functional parameters and Pff V1, we can obtain a exact diagnosis of DHF and comprehensive assessment of left heart function in patients with heart failure. Key words: Diastolic heart failure; BNP; LVEF, LVEDD, LAD;