Quantifizierung von Propofol in der Atemluft mittels endtidaler Ionenmobilitätsspektrometrie

Abstract

Propofol is frequently used as part of total intravenous anesthesia. The use of the substance may result in complications when the dosage is too high as well as too low. In the absence of a monitoring, the application is carried out basing on clinical and vital signs to date. Mass spectrometric detection of propofol previously administered intravenously in human expired air offers a new option of monitoring. In a number of studies, quantification of the substance and possible correlation to intravascular propofol concentration were investigated. Aim of this study is the investigation of an alternative method. Ion mobility spectrometry as an established method in analytical chemistry shows advantages over previously used methods. Calibration serie first performed gives proof of the detectability of propofol in a gas mixture modeled according to the human expired air. For the clinical examination measurements are performed in a surgical patient population. The results show that Propofol can be identified and quantified in the human expired air. The measured concentrations of propofol in expired air show a close correlation to the concentrations in venous serum measured synchronously. By ion mobility spectrometry, the propofol concentration in the serum can be calculated with an average deviation of -10.5%.