Abstract
BackgroundThe aim of the study was to evaluate the impact of integration of the eye-tracking system (ET) on the repeatability of flow density measurements using optical coherence tomography (OCT) angiography.Methods20 healthy subjects were included in this study. OCT-angiography was performed using RTVue XR Avanti (Optovue Inc., Fremont, California, USA). The macula was imaged using a 3 × 3 mm scan twice with and twice without activation of the ET. Flow density data of the macular in the superficial and deep OCT angiograms were extracted and analyzed.ResultsThe difference between the flow density (whole en face) in the first session and second session with and without ET was statistically non-significant (with ET: superficial retinal OCT angiogram: p = 0.50; deep retinal OCT angiogram: p = 0.89; without ET: superficial retinal OCT angiogram: p = 0.81; deep retinal OCT angiogram: p = 0.24). There was no significant difference in the coefficients of repeatability for measurements with and without ET in the superficial retinal OCT angiogram (adjusted p-value = 0.176), whereas the difference was significant for the deep retinal OCT angiogram (adjusted p-value = 0.008).ConclusionsIntegration of the ET improved the repeatability of flow density measurements in the deep OCT angiogram; this needs to be considered when evaluating the long-term changes of flow density and when comparing data of different studies and different devices.
Highlights
The aim of the study was to evaluate the impact of integration of the eye-tracking system (ET) on the repeatability of flow density measurements using optical coherence tomography (OCT) angiography
The flow density, the mean of the absolute difference (AD) between the first and second session, the coefficient of repeatability (CR) and the Intraclass correlation coefficient (ICC) for the two sessions with and without ET are shown in Table 1 and in Table 2
There was no significant difference in the coefficients of repeatability (CR) for measurements with and without ET in the superficial retinal OCT angiogram, whereas for the deep retinal OCT angiogram, the CR for Vessel density 1 p Value p Value
Summary
The aim of the study was to evaluate the impact of integration of the eye-tracking system (ET) on the repeatability of flow density measurements using optical coherence tomography (OCT) angiography. The visualization of normal vessels and pathological neovascularization using OCT angiography has been evaluated in different retinal or choroidal neovascular diseases such as chronic. Another promising aspect of OCT angiography, which could be very useful in clinical practice and for clinical and experimental research, is the ability to quantify blood flow. A new development of the RTVue XR Avanti is the integration of an eye-tracking system (ET) with OCT angiography imaging. The newly introduced software update of this device enables the ET to be activated or deactivated on imaging
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