Abstract
Background and Aims: This post hoc analysis was performed as part of the multicenter, prospective observational trial NEO-ACQUA (NEOnatal Adequate Care for QUAlity of Life), with the aim of investigating QOL in the first 18 months of life of very preterm infants treated or not with surfactant and infants born at term. Methods: Study population is described in the table. Only premature infants without documented neurological pathologies/deficits were enrolled. Table * p < 0.0001 A vs B TAPQOL questionnaire has been performed at 18 months of age. Results: Considering all TAPQOL domains 9/12 in group A, 10/12 in groups B and C displayed a 75th percentile of the score equal to 100, meaning that 25% of the infants achieved the highest value. Only the motor function was statistically different between group A and C (p=0.0007) but not between group A and B. In all three groups the 75th percentile of the motor domain was 100, whereas the 25th percentile was 83.3 (A), 87.5 (B) and 93.7 (C). Conclusions: TAPQOL questionnaire showed that QOL at 18 month among the three groups considered is comparable, in spite of a lower BW and Apgar score in premature infants treated with surfactant. This evidence need to be confirmed by the forthcoming follow-ups. On behalf of: NEO-ACQUA scientific board: M. Agosti, R. Bellú, G. Calciolari, MC. Cavallo, A. Del Prete, R. Zanini
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