Quality of life of patients with cancer of the esophagus and cardioesophageal cancer

Abstract

The urgency of the study is due to the aggressiveness of esophageal cancer and cardioesophageal cancer, low survival rate of patients, the need for further development aimed at improving the consequences of surgical intervention, the effectiveness of which can be evaluated with the help of determining the quality of life of these patients. The aim of the work is to assess the quality of life of patients with esophagus cancer and cardioesophageal cancer after radical surgery, depending on the variant of the formed esophagogastroanastomosis based on the analysis of indicators of the general condition of patients and the severity of esophageal-gastric symptoms at different stages of observation. 60 patients with cancer of the esophagus and cardioesophageal cancer after proximal gastrectomy with resection of the esophagus accesses of Lewis or Osawa Garlock were subject to questioning. The patients were divided into two groups: the study group consisted of 30 patients who had developed the mechanical invagination of the esophagogastro-anastomosis developed and protected by the Ukrainian patent, the comparison group made up 30 patients who had the end-to-side mechanical esophagogastroanastomosis formed. Quality of life was assessed before surgery and at 3, 6, and 12 months after surgery. The EORTC QLQ-C30 V.3 questionnaire was used to assess the general condition of the patients, and the EORTC QLQ-OG25 questionnaire was used to assess the presence of specific gastrointestinal symptoms. Statistical analyses were performed using EZR v.1.35 software (Saitama Medical Center, Jichi Medical University, Saitama, Japan, 2017), which is a graphical user interface for R (The R Foundation for Statistical Computing, Vienna, Austria). To analyze the dynamics of the indicators, the Friedman criterion was used for repeated measurements, pairwise comparisons were performed according to the Conover criterion. To verify the validity of the differences between dependent samples, the non-parametric W-criterion of Wilcoxon was used. It was established that the general condition of the patients after surgery, assessed by the EORTC QLQ-C30 V.3 scales, did not depend on the method of formation of esophagogastroanastomosis. The results of the study of the quality of life of patients after surgery with various ways of forming esophagogastroanastomosis modulo EORTC QLQ-OG25 showed significantly lower frequency rate of symptoms such as reflux, pain and discomfort in the stomach, nutritional problems in front of other people and a sense of physical unattractiveness in the group of patients for which formation of a mechanical invagination esophagogastroanastomosis was applied.