Abstract
This study was done to quality assure the Hawkeye SPECT/CT at the St. Olav’s hospital and create a clinical method for doing individual dosimetry with 177Lu-octreotate in targeted radionuclide therapy for neuroendocrine tumors. Various quality control parameters were performed on Infinia Hawkeye SPECT/CT. A calibration dose of 160% ± 2% MBq was ordered and first calibrated for all the dose calibrators. The uniformity test was obtained using a 40 MBq Tc-99m point source positioned 2.5 m away from the two detectors. A 200 MBq Tc-99m was diluted in 70 ml of water, dispersed in six syringes for the registration test. A Lu-177 point source was placed in front of the detectors, one at a time, to check the energy peaks. The Jaczczak phantom with a hollow sphere set (volumes: 0.5, 1, 2, 4, 8, and 16) ml with an additional 60 ml sphere was used for the 3D sensitivity and recovery with Lu-177. Total activity of 945.3 MBq was added to 160 ml of water yielding an activity concentration of 5.908 MBq/ml in the spheres. The phantom was then scanned at various time intervals. A cylindrical phantom with a volume of 6283 ml was also used to obtain the cross-calibration measurement (cps/MBq). Total activity of 995.6 MBq was added and the phantom was scanned at days 0, 6, 13 and 23. The dose calibration factor was changed from 762 to 760 to achieve correct doses. The 2D mean sensitivity factor was 5.56 cps/MBq. Uniformities for both detectors were approved after iteration calibration of the PM tubes. The X-ray to SPECT registration was found to be accurate and within specifications. The energy peak test revealed off-centered 208 keV energy peaks for the two detectors. Quality assurance of imaging devices using radiation is essential for radiation protection and ensures a high-quality image.
Highlights
Medical imaging provides tremendous and undeniable benefit in modern health care
Various quality control parameters were performed on Infinia Hawkeye SPECT/CT
In the hybrid imaging modalities operation in nuclear medicine, aside from the internal radiation exposure emanating from the administration of radiopharmaceuticals, the external radiation exposure (X-ray) resulting from the CT device has to be considered in light of International Commission on Radiological Protection (ICRP) recommendations [5] [6]
Summary
Medical imaging provides tremendous and undeniable benefit in modern health care. It is used for disease detection, classification, prognostic staging, treatment planning and to validate therapeutic response [1]. In the hybrid imaging modalities operation in nuclear medicine, aside from the internal radiation exposure emanating from the administration of radiopharmaceuticals, the external radiation exposure (X-ray) resulting from the CT device has to be considered in light of International Commission on Radiological Protection (ICRP) recommendations [5] [6]. These recommendations take account of the justification of practices (the use of radiation produces sufficient benefit to offset any risks caused by the use of radiation), optimization (the incurred exposure by the use of radiation should be kept as low as reasonably achievable), and dose limitation. The internal radiation exposure doses of each organ after radiopharmaceutical administration are calculated by the MIRD method [7]
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