Abstract
The production and quality control analysis of short-lived ( t 1/2=2.03 min) oxygen-15 labelled gases ([ 15O ]O 2, [ 15O ]CO, and [ 15O ]CO 2) from a Cyclone 3D accelerator for positron emission tomography (PET) in human subjects has been established and evaluated on a routine basis use at the MRC Cyclotron Unit and are here described. Contaminant levels have been identified and measured by radio-gas chromatography. The maximum levels allowed, measured as a percentage of total delivered activity (v/v), are 3.7% for total nitrogen oxides and 1% for [ 15O ]CO in [ 15O ]CO 2 and [ 15O ]CO 2 in [ 15O ]CO. By adjunction of a cryogenic or molecular sieve trap, radiopharmaceutical gases are routinely produced well within these specifications.
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