Abstract
Small-animal positron emission tomography (PET) is a preclinical imaging method that uses pharmacologically or biochemically active compounds labelled with short-lived positron-emitting radionuclides. This non-invasive nuclear medicine technique requiring animal-dedicated PET cameras (microPET) enables in vivo measurements of physiological processes, biochemical pathways and neurotransmitters. It therefore has a role in studying the pathophysiology and pharmacology of the brain. Moreover, there is increasing evidence that microPET imaging can accelerate drug development by revealing early information regarding biomarkers of pathophysiology or drug mechanisms and cerebral bioavailability. This review presents the potential contribution of microPET in basic neuropharmacology, illustrating its recent contributions and methodological specificities as well as highlighting its limits and constraints. In addition, we aim to encourage the use of PET molecular imaging in basic neuropharmacology to complement other preclinical approaches.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
