Abstract
In Bangladesh about nineteen different Indomethacin marketed preparations (including capsule and suppository) are available. Of them nine brands are Indomethacin capsule dosage forms, potency of which was assayed by UV spectrophotometry and dissolution study was carried out according to the USP pharmacopoeial method to evaluate their quality. The result showed that eight brands of capsules (89%) met the USP specification of potency and the remaining one brand was less potent. All brands were tested for dissolution rate and two brands (23%) failed to meet the specification for dissolution rate. Additional in-vivo bioavailability studies are of utmost importance to draw more conclusive finding regarding quality status of the Indomethacin preparations.
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