QT–DISPERSION AND ALTERATIONS IN LEFT VENTRICULAR MASS INDICES IN KIDNEY FAILURE

Abstract

A112 Aims: A prolonged QT-Dispersion is associated with an increased risk of cardiovascular mortality and can be observed in patients after a myocardial infarction. In patients with kidney failure, the incidence of a myocardial infarction is highly increased. Moreover, dialysis treatment also modulates QT dispersion. In this study, a possible relation between QT-dispersion and left ventricular volume and mass indices should be investigated. Methods: 40 hemodialysis patients (20 with and 20 without coronary heart disease) were investigated. Echocardiography as well as ECG were performed before and after hemodialysis. Results: In patients with CHD, QT-Dispersion increased from 65.45 + 16.2 (SD) ms to 84.90 + 22.25 (SD) ms (p<0.002). In patients without CHD, no significant change in QT dispersion was detected. Echocardiography examination revealed a significant change in LVED from 5.81 + 1.08 (SD) cm to 5.09 + 1.2 (SD) cm (p<0,036) as well as LVVOL (p<0,047) and LVM (p<0,007) in patients with CHD. Correlation analysis showed no significant relation between QT-Dispersion and left ventricular mass and volume indices. Conclusions: This study shows, that changes in QT-Dispersion in hemodialysis patients are independent from alterations in left ventricular mass- and volume indices. Alterations in QT dispersion, however, are associated with CHD.