Abstract
QSAR analysis on a set of synthesized p-Aminosalysilic Acid derivatives analogues tested growth inhibitory antiviral activity was performed by using MLR procedure. The activity contribution of these compounds were determined from regression equation and the validation procedures to analyze the predictive ability of QSAR models were described.The results are discussed on the basis of statistical data. High agreement between experimental and predicted antiviral activity inhibitory values are obtained. The results revealed the significant roles of topological, geometrical and substituent electronic descriptor parameters on the inhibitory activitypIc 50 of coumarin derivative analogues of the studied molecules Key Words: QSAR, Antiviral Activity, MLR
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