Abstract
Objective To evaluate the efficacy of the Qingre Yiqi method in the treatment of type 2 diabetes mellitus (T2DM) with meta-analysis. Method The randomized controlled trials (RCTs) of the Qingre Yiqi method in the treatment of T2DM in the PubMed, Medline, EMBase, Cochrane Library, Web of Science, Weipu Journal, China Knowledge Network (CNKI), and Wanfang database were conducted. Three reviewers independently conducted the screening, extracted the data, and assessed methodological quality. Data analysis was performed using Rev Man 5.3 software for statistical analysis. Results A total of 15 RCTs, including 1440 patients, were included. The results showed that compared with oral hypoglycemic drugs alone, the add-on treatment of the Qingre Yiqi method could significantly improve Chinese medicine syndrome (OR (95%CI) = 3.66 [2.47,5.42], P < 0.00001) and lower the level of HbA1c (MD (95%CI) = −0.68 [0.91, −0.45], P < 0.00001), triglyceride (TG) (MD (95%CI) = −0.38 [−0.58,-0.17], P=0.0004), low-density lipoprotein cholesterol (LDL-C) (MD (95%CI) = −0.25 [−0.37, −0.13], P < 0.0001), and total cholesterol(TC) (MD(95%CI) = −0.40[−0.67, −0.13], P=0.003). In terms of fasting blood glucose (FBG) and postprandial blood sugar (PBG), subgroup analysis showed that the baseline of FBG and the number of combined oral hypoglycemic drugs of PBG were the major sources of heterogeneity. Conclusion Compared with the standard treatment, the Qingre Yiqi method along with oral hypoglycemic drugs showed the more beneficial effects for T2DM on improving TCM syndromes and reducing the blood glucose and partial lipid parameter.
Highlights
type 2 diabetes mellitus (T2DM) is an important public health problem in China
We included studies that met the following inclusion criteria: (1) types of studies: randomized controlled trials (RCTs); (2) type of participants: patients diagnosed with T2DM either using 2020 CDS Guidelines for the Prevention and Treatment of T2DM [1] or 2020 American Diabetes Association diagnostic criteria [12]; (3) main intervention: the control group was treated with oral hypoglycemic drugs, while the experimental group was treated with a traditional Chinese medicine (TCM) prescription based on the Qingre Yiqi method. e definition of the Qingre Yiqi method: 1 the names of the formula include “Qingre Yiqi” or
E aggregated results suggested that the Qingre Yiqi method along with hypoglycemic drugs showed favorable effects for changing fasting blood glucose (FBG) levels of T2DM, while the magnitude of the decrease was related to FBG baseline (Figure 4)
Summary
T2DM is an important public health problem in China. According to the 2017 survey by the China’s National Center for Disease Control and Endocrinology Branch of the Chinese Medical Association, the prevalence rate of T2DM in China is 12.8% [1]. e complications of diabetes involve systemic tissues and organs, especially the damage to the eyes, kidneys, cardiovascular system, and nervous system, which seriously threatens the life quality of patients and brings heavy burden to the society [2]. E excessive endocrine and metabolic activities of the human body were regarded as Evidence-Based Complementary and Alternative Medicine internal heat. TCM considers pathogenesis of DM as “internal heat damages Qi.” erefore, the Qingre Yiqi method, which means clearing the internal heat and supplementing Qi, is often applied in the treatment of DM in Chinese medicine [3]. A number of clinical studies have applied the Qingre Yiqi method on the basis of oral hypoglycemic drugs to relieve clinical symptoms and strengthen the hypoglycemic effect in T2DM. Owing to variation in the sample size and methodological quality of the studies, the efficacy of the Qingre Yiqi method in adjuvant treatment for T2DM was still not fully understood. Owing to variation in the sample size and methodological quality of the studies, the efficacy of the Qingre Yiqi method in adjuvant treatment for T2DM was still not fully understood. erefore, the systematic review and meta-analysis were conducted to provide evidence
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