Q-002 ASSOCIATION OF VON WILLEBRAND FACTOR AND MICROALBUMINURIA WITH THE DEVELOPMENT OF METABOLIC SYNDROME IN CHINESE HYPERTENSIVE PATIENTS

Abstract

Background Endothelial dysfunction plays a key role in atherosclerosis. vonWillebrand factor (vWF) and microalbuminuria (MAU) have been the biomarker of endothelial function. The relationship between vWF and MAU and metabolic syndrome (MS) is yet to be elucidated. This study aims to compare the difference of vWF and MAU between Chinese hypertensives and hypertensive patients with MS, and to explore the association of these factors with the development of MS. Methods According to International Diabetes Federation (IDF 2005) definition of the MS, 133 consecutive Chinese hypertensive subjects were divided into two groups: essential hypertensives (EH group, n = 36) and those with metabolic syndrome (EH + MS group, n = 97). Biochemistry assay, plasma vWF, 24 hours urine albumin excretion (UAE) and morning urine albumin/creatinine ratio (ACR) were measured. The association of vWF and MAU with MS was analyzed. Results Waist circumference, body mass index, triglyceride (TG), low density lipoprotein cholesterol (LDL-C), plasma vWF and UAE were increased(P < 0.05 or P < 0.01, respectively), while high density lipoprotein cholesterol (HDL-C) was decreased (P < 0.01) in EH + MS group, as compared with those in EH group. UAE was positively correlated with ACR (r = 0.707, P < 0.01). vWF was not correlated with UAE or ACR (r = 0.079 and 0.052,P > 0.05, respectively). Logistic regression showed HDL-C, TG, LDL-C,vWF and UAE were associated with the development of MS in hypertensive patients (standardized coefficients: −0.825, 0.63, 0.339, 0.331, 0.371,P < 0.05 or P < 0.01, respectively). Conclusions Compared with essential hypertensives, the Chinese hypertensive patients with MS had more MAU and serious endothelial dysfunction. vWF and MAU were associated with the development of MS in patients with hypertension.