Abstract
A simple and convenient strategy was developed to synthesize a new class of pyrrolidinyl–camphor based bifunctional organocatalysts possessing varying functional linkers. Catalytic screening of these camphor–pyrrolidine linked derivatives for asymmetric Michael reaction of cyclohexanone with β-nitrostyrene was carried out. Various aryl- and heteroaryl-nitroolefins, ketones as well as aldehydes gave the corresponding Michael adducts in high chemical yields (up to 95%) and exceptionally high diastereo-( syn/ anti up to 99:1) and enantioselectivity (up to 95%) using catalyst 6 under solvent-free conditions.
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