Highly Diastereo‐ and Enantioselective Synthesis of 5‐Substituted 3‐Pyrrolidin‐2‐ones: Vinylogous Michael Addition under Multifunctional Catalysis

Huicai Huang, Kailong Zhu + Show 3 more

https://doi.org/10.1002/anie.201008255

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Journal: Angewandte Chemie (International ed. in English)	Publication Date: Mar 4, 2011
Citations: 100

Abstract

Reaction of lactam (I) with α,β-unsaturated ketones provides Michael adducts with high diastereo- and enantioselectivity.

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