Pyridoxal 5′-phosphate 2-methyl-3-furoylhydrazone as a selective sensor for Zn2+ ions in water and drug samples

Abstract

Present paper reports on the synthesis and characterization of novel chemosensor for zinc(II) ion, a hydrazone derived from pyridoxal 5′-phosphate. The conformational diversity of the free ligand was studied by quantum chemistry methods at the B3LYP/ECP10MWB (Zn)/cc-pVTZ (H, C, N, O, P) level of density functional theory, and the optimal structures of free ligand and zinc(II) complex were chosen. The ligand has a selective ability to detect Zn2+ in the aqueous solution, which also contains Na+, K+, Ca2+, Mg2+, Ba2+, Cd2+, Pb2+, UO22+. The detection is based on the formation of the zinc(II) complex, which has the enhanced fluorescent intensity in comparison with that of free hydrazone. The complex was also characterized comprehensively; the stability constant, quantum yield, and structure peculiarities were determined. Potential practical applications of the developed chemosensor for water and drug analysis, as well as bioimaging, were demonstrated.