Pyrazine Derivative as Supramolecular Host for Immobilization of Palladium Nanoparticles for Efficient Suzuki Coupling

Abstract

AbstractPalladium nanoparticles (NPs) have been extensively explored as unique catalyst for carbon‐carbon coupling reactions. Nonetheless, because of extreme tendency of nanoparticles to undergo agglomeration, the immobilization of these metal NPs on organic frameworks is an important area of research. The present investigation demonstrates the synthesis of pyrazine derivative PYZ‐TA as a supramolecular host for holding co‐released Pd NPs derived from the original catalyst (Pd(II)) under standard Suzuki coupling. Unprecedent, physical bars are not required to capture Pd NPs within the pores of supramolecular host. The as obtained catalyst PYZ‐TA@Pd exhibits high potential to undergo self‐assembly in solid as well as in liquid state. The PYZ‐TA@Pd ensemble shows high catalytic activity and recyclability (up to seven cycles) in Suzuki‐Miyaura coupling reactions using low palladium loading and provides the corresponding products in excellent yields (up to 98 %). Therefore, this study provides an efficient strategy to develop an easy to synthesize palladium centered solid catalyst through coordination between organic host and Pd NPs.