Abstract
The title compound, C4H4N2S, was obtained by the reduction of 2-mercapto-pyrazine (during its crystallization with 2-mercapto-pyrazine and isonicotinic acid N-oxide in ethanol solution. It crystallizes in the monoclinic space group P21/m. In the crystal, the mol-ecules are linked by N-H⋯N and C-H⋯S hydrogen bonds.
Highlights
Pyrazine is an aromatic six-membered hetrocyclic that contains two nitrogen atoms in positions 1 and 4
Pyrazine derivatives play an important role in chemotherapy (Wu et al, 2012; Polshettiwar & Varma 2008; Goya et al, 1997)
Pyrazine-2(1H)-thione crystallizes in the monoclinic space group P21/m
Summary
Pyrazine is an aromatic six-membered hetrocyclic that contains two nitrogen atoms in positions 1 and 4. 2-mercaptopyrinosine derivatives are known to be cancer inhibitors (Mallesha & Mohana, 2011; Bonde & Gaikwad, 2004). The title compound pyrazine-2(1H)-thione (I) was obtained as a yellow solid by reduction of 2-mercaptopyrazine (II) during its crystallization with 2-mercaptopyrazine (II) and isonicotinic acid N-oxide (III) in ethanol solution (Fig. 1). The C—C bond lengths are within the expected values known for aromatic systems. The N1—C2 and N1—C6 bond lengths [1.354 (3) and 1.355 (3) A , respectively] are longer than those for N4—C3 and N4—C5 [1.299 (3) Aand 1.366 (3) A )], respectively. This is the result of the protonation of the N1 atom.
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