Abstract
The analysis of the nucleoprotein gene of 77 Puumala hantavirus strains detected in human samples in France during 2012–2016 showed that all belonged to the Central European lineage. We observed 2 main clusters, geographically structured; one included strains with the Q64 signature and the other strains with the R64 signature.
Highlights
The analysis of the nucleoprotein gene of 77 Puumala hantavirus strains detected in human samples in France during 2012–2016 showed that all belonged to the Central European lineage
Genomic findings from this study revealed that the 77 Puumala virus (PUUV) strains studied and detected in humans in France during 2012–2016 all belonged to the Central European lineage
The strains were clustered within 2 sublineages, with marked geographical patterns: the first included strains with the Q64 signature, a hallmark of strains from Belgium, and the second carried an arginine (R) at position 64
Summary
The analysis of the nucleoprotein gene of 77 Puumala hantavirus strains detected in human samples in France during 2012–2016 showed that all belonged to the Central European lineage. Within the variant PUUV, 8 lineages have been described, according to phylogenetic analysis of the small (S) RNA segment coding domain sequence (CDS) of the strains. PUUV is the main hantavirus detected in France.
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