Abstract
Putting the brakes on acute lung injury: can resolvins suppress acute lung injury?
Highlights
Acute lung injury (ALI), a syndrome of respiratory failure, is a major clinical problem in the United States
To investigate the potential role that Resolvin D1 (RvD1) may play in the resolution of ALI, Eickmeier et al used a murine aspiration pneumonitis acute lung injury (APALI) model induced by hydrochloric acid (HCl) administration into the left lung
Utilizing an intra-venous administration of the more stable form of RvD1, aspirin-triggered resolvin D1 (AT-RvD1), Eickmeier et al demonstrated that the conversion of docasahexaenoic acid (DHA) in pulmonary mucosa alleviates the effects of inflammation in APALI
Summary
A commentary on Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury by Eickmeier, O., Seki, H., Haworth, O., Hilberath, J. Acute lung injury (ALI), a syndrome of respiratory failure, is a major clinical problem in the United States. ALI is characterized by pulmonary edema, deterioration of the alveolar-capillary membrane and an aggressive inflammatory response.
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