Abstract
Uttroside B from Solanum nigrum Linn. exhibited potent cytotoxicity against HepG2 cells with an IC50 of 0.5 μM; interestingly, its congeners uttroside A and uttronin exhibited the same level of activity. We hypothesized that spirocyclization is the critical step for the activity of uttroside A or B that results in the formation of uttronin. To support our hypothesis, an uttroside B analogue was synthesized that cannot undergo spirocyclization, which resulted in a loss of cytotoxic activity. Mass spectral analysis of the supernatant from the cells treated with uttroside B further supported the spirocyclization of uttroside B to uttronin.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
