Purpuracenin: a new cytotoxic adjacent bis-tetrahydrofuran annonaceous acetogenin from the seeds of Annona purpurea.

Abstract

Purpuracenin, a novel cytotoxic acetogenin and annaglaucin, a known compound, were isolated from the seeds of Annona purpurea. Their structures were elucidated by a combination of chemical and spectral methods including MS and NMR spectral measurements. The absolute configurations of both compounds are presented. The new compound and annoglaucin exhibited potent cytotoxic activity in vitro against six human solid tumor cell lines.