Abstract
Introduction: Aging can occur in all parts of the body. Superoxide dismutase (SOD) enzyme is an enzyme that interacts with collagen, especially in types I and IV. UVB rays can trigger the presence of free radicals and lipid peroxidation, which form malondialdehyde (MDA) compounds. This study aimed to determine the effect of cream application of purple sweet potato (Ipomoea batatas L.) extract on increasing the ratio of SOD to MDA levels and increasing collagen in rats exposed to UVB. Methods: This was experimental, using a post-test only with a control group design. The irradiation was carried out for 4 weeks with a total radiation dose of 840 mJ/cm2. Purple sweet potato cream concentration was 4%, 8%, and 16%. Rat blood was taken to check the ratio of SOD/MDA and collagen levels using the ELISA kit and Sirius red staining. This study used descriptive analysis and ANOVA using SPSS.25.sav Results: The highest ratio of SOD/MDA levels was found in the treatment group with an 8% purple sweet potato extract concentration of 3.346 ± 0.113. In the collagen expression, the highest percentage was found at 8% levels of 83,290 ± 1,885%. There was a significant mean difference between the treatment and control groups, with the treatment group having a higher result than the control group (p<0.001). Conclusion: The administration of purple sweet potato cream extract could inhibit aging by increasing the ratio of SOD/MDA levels and collagen expression.
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