Abstract
1. 1. Dextran precipitated sensitizing and precipitating antibodies from Type II antipneumococcal rabbit serum. All detectable antidextran precipitins were precipitated by dextran in the zone of hapten excess. 2. 2. Dextran elicited anaphylactic shock in guinea pigs that had been sensitized passively with Type II antipneumococcal rabbit serum. 3. 3. Dextranase denatured dextran in saline and in protein solutions and in insoluble complexes with precipitated antibody. 4. 4. Dextranase eluted all readily detectable dextran from dextran-antidextran precipitates. The resulting “purified” antibody precipitated with and passively sensitized guinea pigs against dextran. 5. 5. Antibody which had been purified three times still sensitized against and precipitated with dextran. 6. 6. Purified antibody solutions still exhibited the phenomenon of dominant and recessive haptens. 9
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