Abstract
BackgroundThe present study aimed to purify and modify the neem gum (NG) to evaluate its dispersing ability in a pharmaceutical suspension formulation. The modification was carried out to cross-link the sugars as carbamate in the presence of calcium chloride to improve the suspending property. Physiochemical properties such as pH, solubility, swelling index and ash value were performed before investigating the dispersing potential. The suspending potential of neem gum was studied in its different forms such as purified and modified gum in paracetamol suspension and was compared with sodium carboxymethylcellulose (CMC) being used as standard at a concentration range of 0.25–1% (w/v). The test suspensions were evaluated for the redispersibility, flowability, sedimentation volume (%) and stability study for 3 months.ResultThe redispersibility of modified neem gum (MNG) was found equal to CMC at a higher concentration. The flowability and apparent sedimentation of test suspending agents and CMC were found in the order of NG > MNG > CMC. It showed a positive correlation with the viscosity of suspension formulations. All the test paracetamol suspension formulations were found stable in the stability study.ConclusionThe findings of the present study showed that as an alternate suspending agent, modified cross-linked neem gum could be used.
Highlights
The present study aimed to purify and modify the neem gum (NG) to evaluate its dispersing ability in a pharmaceutical suspension formulation
Collection and purification of neem gum The tears of the neem gum were collected from the neem plants from Shirpur vicinity
The powdered gum was purified by dissolving it in hot distilled water followed by precipitating in alcohol
Summary
The present study aimed to purify and modify the neem gum (NG) to evaluate its dispersing ability in a pharmaceutical suspension formulation. The modification was carried out to cross-link the sugars as carbamate in the presence of calcium chloride to improve the suspending property. Physiochemical properties such as pH, solubility, swelling index and ash value were performed before investigating the dispersing potential. Gums are ideal natural polymer for pharmaceutical emulsion and suspension formulations by increasing the viscosity of the continuous phase. It increases the tensile strength, by hydrogen bonding and molecular interactions, of the hydration layer formed around the suspended particles without minimizing the surface and interfacial tension. A few studies were done for its binding and sustained release property [2]
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