Abstract

Pulsed release of antidepressants from nanocomposite hydrogels

Highlights

  • In recent years we have proposed some polyelectrolyte hydrogels, of anionic and ampholyte nature, capable of complexing, besides metal ions, with metal-based drugs and drug molecules containing amino functionality [1,2,3]

  • New stimuli-responsive hydrogels based on -amino acid residues can be considered as promising platforms for chrono-therapeutic applications, as they respond to external triggers [1,2,4,5,9,10,11]

  • The pulsed release of drugs is a new delivery system that certainly provides an increase in therapeutic benefit to patients suffering from chronic diseases, because it delivers the drug in the right amount at the right time and place

Read more

Summary

Introduction

In recent years we have proposed some polyelectrolyte hydrogels, of anionic and ampholyte nature, capable of complexing, besides metal ions, with metal-based drugs and drug molecules containing amino functionality [1,2,3]. Anionic hydrogels show different critical conditions at which the whole swollen mass completely collapse at pH 4 and pH 5 due to the compounds bearing the L-valine and the L-phenylalanine residues, respectively [1,2,3]. Such critical pH values are related to their thermodynamic properties, as revealed from the study of the free polymers in aqueous solution [7,8]. Because of the many diseases that follow the circadian rhythms of the body, the goal in drug delivery

Methods
Results
Conclusion
Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.