Abstract
A study was conducted in mice to teat the efficacy of pulsed electromagnetic fields (PEW) as a means of reducing acute and chronic skin ulceration from two model vesicant anticancer drugs. Adult female BALB/c mice were dehaired dorsally and given 0.5 mg intradermal injections of the DNA intercalators, doxorubicin and bisantrene. The mice-re then housed in plexiglass cages and exposed to 2-Hz PEMF of repetitive pulse bursts of 250 μsec or 20 μsec duration. Skin lesions and survival were assessed daily. There was no significant skin toxicity reduction with either PEMF treatment for doxorubicin (acute ulceration) or bisantrene (chronic ulceration). The inclusion of topical DMSO treatments also did not reduce skin ulceration and appeared to increase doxorubicin lethality. The PEMF treatments appeared to slightly increase some of the vesicant ulcers and doxorubicin lethality.
Highlights
Recent studies have shown t h a t pulsed, low energy electromagnetic fields (PEMF) can enhance the healing of nonunion fractures ( l, Z ), facilitate nerve regeneration ( 3 ), and reduce persistent inflammation of joints ( 4 )
The lowest peak ulcersizems obtained with PEMF controlunitJin which the device was not activated
There was a l s o no significant doxorubicin toxicity reduction f o r the PEMF regimens combined with topical DMSO
Summary
Recent studies have shown t h a t pulsed, low energy electromagnetic fields (PEMF) can enhance the healing of nonunion fractures ( l , Z ) , facilitate nerve regeneration ( 3 ) , and reduce persistent inflammation of joints ( 4 ). Because of the severe nature of such vesicant-induced skin ulcers , a mmber of antidotal approaches have been systematically evaluated using experimental animal models [10,11,12,13,14,15,16,17,18]. Most of these approaches have involved phamacologic or topical temperature modifications t o reduce rodent or pig skinulcers. There a r e no studies which have attempted t o evaluate the possible antidotalroleforpulsatile electromagnetic fieldsin managing vesicant-induced skin ulcers
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