Abstract
Mucus gland adenoma is an extremely rare benign lung tumor, presumed to arise from the bronchial mucus glands; it is a TTF-1 negative tumor, centrally located, causing the clinical manifestations of obstruction. We report a TTF-1 negative mucus gland adenoma, arising into the medial bronchopulmonary segment, lacking any relation to a bronchus.
Highlights
Mucus gland adenoma of the lung represents a genuine adenoma of salivary gland type, characterized microscopically by mucus-filled cysts, acini and glandular structures, lined by a single layer of epithelial cells having not, or only exceptionally, the features of cytological atypia [7]
Mucus gland adenoma is a rare disease of the bronchial tree
No parenchymal location for such a tumor has been reported to date and the only mucus gland adenoma described peripherally [3] was, an acinar lesion arising from a dilated bronchus, covered by pseudostratified ciliated columnar epithelium [3]
Summary
Mucus gland adenoma of the lung represents a genuine adenoma of salivary gland type, characterized microscopically by mucus-filled cysts, acini and glandular structures, lined by a single layer of epithelial cells having not, or only exceptionally, the features of cytological atypia [7]. Microscopic examination of the resected specimen showed an area of neoplastic mucus glands lined by a single layer of tall columnar cells, with basal located nuclei and abundant mucus-filled supranuclear cytoplasm (Figures 1(b) and 1(c)). Mucus gland adenoma is a rare disease of the bronchial tree.
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