Abstract
Hyperpolarized 83Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the 83Kr hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched 83Kr, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized 83Kr MRI after krypton inhalation. Different 83Kr relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T1 weighted hyperpolarized 83Kr MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast.
Highlights
Pulmonary MRI with hyperpolarized 129Xe [1] and hp 3He [2] are emerging techniques for spatially resolved measurement of lung function that cannot be obtained by alternative non-invasive methods
Pumps that have been used for extraction and compression of 3He after metastable exchange optical pumping (MEOP) [24] typically require many compression cycles to transfer the entire hp gas volume [24,25,26,27]
surface quadrupolar relaxation (SQUARE) may originate from a deeper layer or may be caused by interactions of the krypton atoms with the outer surfactant layer
Summary
Pulmonary MRI with hyperpolarized (hp) 129Xe [1] and hp 3He [2] are emerging techniques for spatially resolved measurement of lung function that cannot be obtained by alternative non-invasive methods. Both non-radioactive isotopes have a nuclear spin I = 1/2 that can be hyperpolarized through laser-based methods [3,4] to. The 3He spin relaxation is more affected by the presence of paramagnetic O2 in the gas phase than that of any other noble gas isotope and the 3He
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