Abstract
Pulmonary MicroRNA Expression Profiles Associated with Subchronic Aspergillus fumigatus Exposure.
Highlights
Aspergillus fumigates (A.fumigatus) is a saprophytic fungus that plays an essential role in recycling environmental carbon and nitrogen[1].Environmental surveys indicate that all humans will inhale at least several hundreds of A. fumigates conidia per day
Examination of the miRNA profile post-fungal exposure demonstrated a large number of altered miRNAs, study by Denning support previously reported immune responses following A. fumigatus exposure, altered miRNAs may serve as potential biomarkers to evaluate fungal exposure[4]
Summary The genus Aspergillus is extraordinary as exemplified by the diversity of its disease manifestations, almost all termed ―aspergillosis‖
Summary
Aspergillus fumigates (A.fumigatus) is a saprophytic fungus that plays an essential role in recycling environmental carbon and nitrogen[1]. Aspergillus fumigatus causes the majority of cases of aspergillosis, followed by A. flavus, A. niger, A. terreus and A. nidulans [6](7). (Fig:1): Diagram of terminology used for the identification of Aspergillus species When grown in culture, the teleomorphs of Aspergillus form the typical fruiting bodies of the ascomycetes, called ascomata, ascomata are spherical structures containing globose asci usually with. Virulence factors of aspergillus: Fatal experimental infections leading to multiple organ involvement have been most frequently produced in mice with an intravenous injection of conidia that compared the virulence of different species, in general, A. flavus seemed to be more virulent than other Aspergilli of clinical interest [10]. Fumigatus is by far the most frequent species present in such infections, followed at some distance by A. flavus, A. niger, A. terreus, A. nidulans and A. ustus, and with a lower percentage Neosartorya spp, Significantly, in recent years the proportion of infections caused by non-fumigatus Aspergillus species has increased considerably (table 1) [13].
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