Abstract
<h2>Abstract</h2> An <i>in situ</i> pulmonary lobe perfusion study was undertaken to examine the role of stored blood in the pathogenesis of posttraumatic pulmonary insufficiency. Autologous blood was stored for 21 days in ACD solution, passed through a standard blood-set filter and perfused for 2 hr through the left lower lobe of seven dogs and seven baboons. Seven animals of each species were perfused with autologous filtered blood stored for 24 hr and served as controls. Perfusion with stored blood resulted in significantly increased pulmonary vascular resistance (PVR), end-inspiratory bronchial pressure (P<sub>b</sub>), and lung water in both baboons and dogs relative to controls. The arteriovenous pO<sub>2</sub> gradient was significantly decreased in the dog perfusion group while a definite downward trend was noted in the baboon group but lacked statistical significance. Gross and microscopic evidence of pulmonary edema was noted in both groups and the great majority of animals in both species demonstrated perivascular hemorrhage, intraalveolar edema, and hemorrhage and alveolar congestion in response to perfusion with stored blood. The screen filtration pressure (SFP) was immeasurably high in all baboon blood stored 3 weeks in ACD solution. This resembles the response previously noted in stored human blood. In contrast, stored dog blood fails to show a consistent elevation in SFP relative to control blood.
Published Version
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