Abstract
Pulmonary hyalinizing granuloma is a very rare benign condition. This study describes a case involving pulmonary hyalinizing granuloma in a 76-year-old man who presented with a solitary pulmonary nodule, determined through chest radiography and computed tomography, that mimicked primary lung cancer. To establish a definitive diagnosis, tumor resection was performed with histopathological analysis indicating pulmonary hyalinizing granuloma. Radiographic findings in previously reported cases showed that most patients had well-defined margins and usually bilateral, multiple lesions. In our case; however, the solitary ill-defined tumor mimicking lung cancer is an uncommon location for this rare condition.
Highlights
Pulmonary hyalinizing granuloma (PHG), a rare benign tumorous lesion mimicking a pulmonary neoplasm, occurs as a single or multiple lesions with unilateral or bilateral lung involvement
1: (a) Chest X-ray revealing an irregular shadow in le lower field. (b) Chest computed tomography (CT) in the lung window revealing a tumor located at S8 of the le lower lobe. (c) Chest CT in the mediastinal window showing a tumor with suspected pleural invasion
46 Male Female Single Multiple Primary lung squamous cell carcinoma Emphysematous merger interstitial pneumonia Collagen disease Hypergammaglobulinemia Non Lung cancer Lung cancer suspicion Metastatic lung cancer suspicion ymoma suspicion None Lobectomy Partial excision Follow up FDG-positron emission tomography (PET)/CT performed in 4 cases including this case
Summary
Pulmonary hyalinizing granuloma (PHG), a rare benign tumorous lesion mimicking a pulmonary neoplasm, occurs as a single or multiple lesions with unilateral or bilateral lung involvement. A definite diagnosis certainly requires pathologic evaluations. PHG is histologically characterized by vitrified collagen fiber bundles and surrounding lymphocytes and plasma cells. This disease was first characterized in 1977 by Engleman et al [1], the details still remain unknown. PHG has been thought to be associated with mediastinal and retroperitoneal fibrosis as well as autoimmune, hematologic, thromboembolic, and infectious diseases
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