Abstract
Pulmonary Hemorrhage in Infants
Highlights
ADENOVIRUSES ARE COMMON PATHOgens that often are associated with respiratory and gastrointestinal illness and/or conjunctivitis in young persons
In 1996, the sole manufacturer ceased production of adenoviral vaccines and, as supplies dwindled during the few years, outbreaks of adenoviral respiratory illness reemerged in military settings
Chloroquine, ideally taken with daily proguanil, had been recommended only for persons unable to take mefloquine or doxycycline
Summary
ADENOVIRUSES ARE COMMON PATHOgens that often are associated with respiratory and gastrointestinal illness and/or conjunctivitis in young persons. Adenovirus serotypes 4 and 7 have caused outbreaks of self-limited febrile respiratory illness in young adults in basic military training. In 1996, the sole manufacturer ceased production of adenoviral vaccines and, as supplies dwindled during the few years, outbreaks of adenoviral respiratory illness reemerged in military settings.. 1999, approximately 10%-12% of all recruits have become ill with adenovirus infection in basic training, similar to the prevaccine era. This report describes the first two deaths probably associated with adenovirus infection identified in military recruits since the vaccines became unavailable. The military has requested proposals for a new adenovirus vaccine manufacturer; these deaths suggest that efforts by policymakers and pharmaceutical companies to reestablish adenoviral vaccine production should be intensified
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