Abstract
Abstract Background: Pulmonary arterial hypertension (PAH) pulmonary hypertension (PH) presents a complex pathobiology. Individuals with end-stage kidney disease, particularly those undergoing hemodialysis (HD), face an elevated risk of PH development. Early identification of PH severity in chronic kidney disease (CKD) can facilitate timely interventions to mitigate cardiovascular mortality. Our study aimed to determine the prevalence of PAH in CKD patients and explored its association with different CKD stages. Materials and Methods: A hospital-based cross-sectional study involving 60 CKD patients was conducted. Pulmonary arterial pressures were assessed using Doppler echocardiography, and patients were stratified into groups based on PH severity. Results: In our study, 86.7% of CKD patients had PAH, and their mean pulmonary arterial systolic pressure (PASP) was 50.83 ± 9.779 mmHg. There was a significant increase in PH prevalence with advancing CKD stages (P < 0.001). Patients undergoing HD exhibited a substantial PH prevalence (63.5%) (P < 0.001) as compared to those receiving conservative treatment. Furthermore, pulmonary arterial pressures were greater in HD patients with an arteriovenous fistula (AVF) (44.2%) (P < 0.001) than in individuals with a femoral or jugular vein HD catheter. Conclusion: Nearly four-fifth of CKD patients had PAH. In addition, individuals undergoing dialysis with an AVF demonstrated significantly elevated pulmonary arterial pressures compared to those using a femoral or jugular vein HD catheter.
Published Version
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