Abstract
Traditional medicines have to turn out to be the most desired approach to lessen the damaging effects of type-2 diabetes and its stern problems as a result of minor effects and reduced cost. Lately, the anti-diabetic activity of Puerarin has been documented, but the mechanism of actions has not been elucidated. This study designed to assess the molecular relations obtainable between Puerarin, a compound isolated from Pueraria lobata and targeted receptors linked to Type 2 diabetes mellitus. These processes include the molecular modeling of Puerarin to 5 receptors: peroxisome proliferator-activated receptor - gamma (PPARγ), 11-β hydroxysteroid dehydrogenase type 1 (11-β HSD1), glutamine: fructose-6-phosphate amidotransferase (GFAT), protein-tyrosine phosphatase 1B (PTP1B) and mono-ADP-ribosyltransferase sirtuin-6 (SIRT6). Following the outcomes of docking of Puerarin with the five different receptor proteins, revealed that Puerarin is a potent inhibitor which binds well with the different receptors relevant to type-2 diabetes. The pharmacophore features also revealed hydrophobic interactions, hydrogen bond acceptors, and hydrogen bond donors. Hence, the results provided insights into the development of better Puerarin as a replacement to present diabetic management.
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